26 lines
4.5 KiB
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26 lines
4.5 KiB
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<h1>Zk | See? Wheee!</h1>
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<p><span class="tag">diary</span> <span class="tag">livejournal</span> <span class="tag">fossils</span></p>
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<p>In 1998, Robert Furchgott, Louis ignarro, and Ferid Murad won the Nobel prize in Physiology/Medicine for signaling in the endothelium. Robert Furchgott tested drugs originally on rabbit aortas. He received contradictory results, thus finding that an intact endothelium is was needed. He came up with the concept of the EDRF, the Endothelium Derived Relaxing Factor. Louis Ignarro tested hemoglobin exposure to pre-contracted bovine arteries, finding that the EDRF was Nitric Oxide. Ferid Murad found that Nitric Oxide was the signaling molecule for myosinic relaxation and proved that to be true.</p>
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<div class="codehilite"><pre><span></span><code><span class="nv">Endothelial</span> <span class="nv">cells</span> <span class="nv">are</span> <span class="nv">squamous</span> <span class="nv">cells</span> <span class="nv">acting</span> <span class="nv">as</span> <span class="nv">a</span> <span class="nv">barrier</span> <span class="nv">in</span> <span class="nv">the</span> <span class="nv">in</span> <span class="nv">the</span> <span class="nv">blood</span> <span class="nv">vessels</span> <span class="nv">between</span> <span class="nv">blood</span><span class="o">-</span><span class="nv">flow</span> <span class="nv">and</span> <span class="nv">the</span> <span class="nv">smooth</span> <span class="nv">muscle</span> <span class="nv">tissue</span>. <span class="nv">Nitric</span> <span class="nv">Oxide</span> <span class="nv">can</span> <span class="nv">induce</span> <span class="nv">contraction</span> <span class="nv">in</span> <span class="nv">these</span> <span class="nv">cells</span>. <span class="nv">Signaling</span> <span class="nv">by</span> <span class="nv">means</span> <span class="nv">of</span> <span class="nv">a</span> <span class="nv">gas</span> <span class="nv">was</span> <span class="nv">a</span> <span class="nv">new</span> <span class="nv">concept</span> <span class="nv">in</span> <span class="nv">biology</span>. <span class="nv">The</span> <span class="nv">significance</span> <span class="nv">of</span> <span class="nv">this</span> <span class="nv">is</span> <span class="nv">that</span> <span class="nv">Nitroglycerine</span>, <span class="nv">prescribed</span> <span class="k">for</span> <span class="nv">heart</span> <span class="nv">troubles</span> <span class="nv">can</span> <span class="nv">reduce</span> <span class="nv">pain</span> <span class="nv">due</span> <span class="nv">to</span> <span class="nv">angina</span> <span class="nv">pectoris</span> <span class="nv">by</span> <span class="nv">increasing</span> <span class="nv">blood</span> <span class="nv">flow</span>. <span class="nv">It</span> <span class="nv">can</span> <span class="nv">also</span> <span class="nv">reduce</span> <span class="nv">dangerously</span> <span class="nv">high</span> <span class="nv">blood</span> <span class="nv">pressure</span> <span class="nv">in</span> <span class="nv">the</span> <span class="nv">lungs</span> <span class="nv">of</span> <span class="nv">infants</span>, <span class="nv">and</span> <span class="nv">may</span> <span class="nv">help</span> <span class="nv">with</span> <span class="nv">tumor</span> <span class="nv">reduction</span> <span class="nv">by</span> <span class="nv">inducing</span> <span class="nv">apoptosis</span>. <span class="nv">NO</span> <span class="nv">was</span> <span class="nv">also</span> <span class="nv">crucial</span> <span class="nv">in</span> <span class="nv">the</span> <span class="nv">development</span> <span class="nv">of</span> <span class="nv">Viagra</span>, <span class="nv">as</span> <span class="nv">well</span> <span class="nv">as</span> <span class="nv">the</span> <span class="nv">diagnosing</span> <span class="nv">of</span> <span class="nv">asthma</span>, <span class="nv">colitis</span>, <span class="nv">and</span> <span class="nv">other</span> <span class="nv">diseases</span>
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</code></pre></div>
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<p>Page generated on 2004-09-22 23:05:22</p>
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